I'm fascinated by the subject matter, and found for the most part that the stories related to each chapter heading (typically the name of a type of brain tumor) piqued my interest and intrigue. In time, however, I came to realize that the self-effacing writer was a bit of a downer. Sure, I get it that in his field there is no lack for tragedy. At one point he even admitted to the belief that there aren't any miracles in his field. My response to that is, "Not even one?" Sure, there were stories that hinted at good outcomes, but for the most part Marsh seems bent on relating only failures, poor outcomes, tragedies. Maybe it's the European cultural influence, and as an American I'm a hopeless optimist, but I wanted to get in Marsh's ear and ask him if his entire career seems as futile to him as his book implies.