This book is an interesting insight into the current research being performed in the field of aging and genetics. Dr. SInclair makes a compelling argument that aging is actually a disease rather than a "natural condition" that humanity must accept. There is quite a bit of science and medical/genetic research throughout the first half of the book, which personally, I found fascinating. He goes a bit off course more than halfway through the book when he begins to opine on what he feels are related topics such as global climate change, over-population, mankind's addiction to consumption of natural resources, and Earth's ecosystems inability to support all of the above. He also addresses the moral question of whether we should live longer or not. He makes no secret that he considers himself to be a globalist, humanist. While I may not agree with some of his opinions, he nonetheless is passionate about his work and is very conscientious about the impact that it may have in shaping the future of the world. Overall, it's an interesting read, but it could have been shortened greatly without the circumstantial diatribe on varying geopolitical issues such as energy consumption, use of natural resources, and political despotism against genetic research.